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Abstract

COMPARATIVE STUDY ON EFFECT OF NATURAL AND SYNTHETIC SUPERDISINTEGRANT ON FORMULATION OF SUBLINGUAL TABLET OF AMLODIPINE BESYLATE

Raosaheb R. Dhangar*, Dr. S. T. Patil, S. A. Tadavi and Dr. S. P. Pawar

Abstract

Amlodipine besylate which is generally taken to reduce hypertension. In this study an attempt has been made to formulate a dosage form of amlodipine using synthetic superdisintegrant crosscarmellose sodium to show that this synthetic superdisintegrant will show better disintegrating property than the natural superdisintegrant like sodium guar gum in the formulation of sublingual tablet of amlodipine besylate. Sublingual tablet prepared by direct compression technique using natural & synthetic superdisintegrant in different concentration & evaluated. Among all F6 is an optimized formulation of crosscarmellose sodium that releases the drug above 90% within 60 min. as compared to all formulations of natural superdisintegrant which is a guar gum preparation.

Keywords: Amlodipine besylate, sublingual tablets, Superdisintegrant.


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