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Abstract

FORMULATION AND EVALUATION OF PANTOPRAZOLE BUCCAL PATCHES:- A REVIEW

Ankit Singh*, Pallavi Tiwari, Preeti Saxena, Sagar Singh Jough, Akash Srivastva,
Dharmendar Kumar

Abstract

Buccal delivery of drugs provides an attractive alternate to other conventional methods of systemic drug administration, since buccal mucosa is relatively permeable with rich blood supply and acts as an excellent site for the absorption of drugs. The administration of drugs via buccal route facilitates a direct entry of drug molecules into the systemic circulation, avoiding the first-pass metabolism and drug degradation in the harsh gastrointestinal environment, which are often associated with oral administration. The buccal cavity is easily accessible for self medication. The buccal cavity is easily accessible for self medication, and hence it is safe and well accepted by patients, since buccal patches can be very easily administered and even removed from the application site, terminating the input of drug whenever desired. The strategies include manipulation of the formulation (e.g. inclusion of penetration enhancers or protease inhibitors etc.), maximizing retention of the delivery system at the site of absorption, and alteration of the peptide so as to optimize affinity for endogenous transport systems, build in chemical and metabolic stability, minimize the size and optimize the balance between lipophilicity and hydrogen bonding potential. The aim of the present investigation was to formulate and evaluate buccal patches comprising drug (atenolol) containing mucoadhesive polymeric layer (using SA, CP 934 P, NaCMC and HPMC) and drug free backing membrane composed of PVAaluminumfoil. Aluminum foil was used with adhesive polymer PVA to prevent back release of the drug from the buccal patches.

Keywords: Buccal delivery, Patches, Gastrointestinal drug.


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