Abstract

PRELIMINARY BIOCHEMICAL AND PHARMACOLOGICAL EVALUATION OF SIDDHA FORMULATION SIVANAR VEMBU CHOORANAM

*B. Sundar Ahmed

Abstract

Sivanar vembu Chooranam (SVC) is a single herbal formulation which is being used clinically for the treatment of several types of skin diseases and it is exclusively used for the effective management of Kalanchaga padai (Psoriasis). Although this disease may not affect the survival of the patients, the chronic stable plaques may also progress rapidly with symptoms such as intense pruritis and burning and can affect the quality of life. The present study was conducted in-vivo using experimental animal models of albino rats with water extract of SVC for evaluating the analgesic, acute and chronic anti inflammatory activity and the results were compared with standard drugs paracetamol and ibuprofen respectively. In-vitro model of guinea pig ileum was used as to evaluate the antihistaminic activity in which the study drug SVC was given to observe the inhibitory effect of histamine induced contractions. Preliminary qualitative analysis of biochemical constituents was also performed to have a basic knowledge of the phytoconstituents responsible for the pharmacological action of Sivanar vembu Chooranam (SVC). Upon comparing the pharmacological action of SVC with standard drugs, the results showed that the single herbal formulation SVC had good analgesic, moderate anti-inflammatory and significant anti histaminic effect.

Keywords: Siddha, Sivanar vembu Chooranam (SVC), analgesic action, anti inflammatory activity, antihistaminic activity, Herbal drugs.