Abstract

PREPARATION AND CHARACTERIZATION OF POLY (D, LLACTIDE- CO-GLYCOLIDE) NANOPARTICLES CONTAINING CLOPIDOGREL BISULFATE

A.Sumathi *, T.N.K. Suriyaprakash

Abstract

Clopidogrel bisulfate, a potent oral antiplatelet agent, is a drug of first choice used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. PLGA nanoparticles loaded with clopidogrel bisulphate were prepared with 5 ratios and then characterized with respect to size, surface morphology, entrapment efficiency, invitro drug release profile and stability studies under specific conditions. The diameter of particles was ranging from 120 nm to 600 nm. The highest cumulative percentage of drug release (98.01 %) was observed with F1, whose entrapment efficiency was 48.18 % and contains Clopidogrel bisulfate/PLGA in the ratio of 15/85 %.

Keywords: Platelet, Clopidogrel, Nanoparticles, PLGA.