Abstract

SYNTHESIS AND IDENTIFICATION OF SEVERAL SCHIFF BASES DERIVATIVES AND THEIR ANTIBACTERIAL ACTIVITY ON COMMON PATHOGENIC BACTERIA

Zahraa Yosif Motaweq, Hawraa Mohammed Sadiq, Nibras Yahya Alsallamiand, Mohauman Mohammad AL-Rufaie*

Abstract

This research involves synthesis of some Schiff base compounds [A1- A3] were prepared from condensation of [4-(dimethylamino) benzaldehyde and 4-hydroxy benzaldehyde and 4-chloro benzaldehyde] in absolute ethanol. Each from the prepared compounds are distinguished with [FT.IR] spectroscopy, additionally to the progression of the steps of reaction through the technique of [TLC], by utilizing (ethanol-toluene,1:1) as solvent .The following scheme[1] explains the steps of reaction and the prepared compounds. Antibacterial efficiency of A1, A2 and A3 compounds were tested against eight human pathogens like two gram +ve bacteria (Staphylococcus aureus, Streptococcus agalactiae) as well as five gram -ve bacteria (Escherichia coli, Enterobacter cloacae, Proteus mirabilis, Klebsiella pneumoniae, Pseudomonas aeroginosa and Salmonella typhi) using agar well diffusion method. All compounds showed significant activity against pathogenic bacteria, but the A2 compound showed maximum inhibition zone and antibacterial activity against all pathogenic bacteria. The minimum inhibition zone was determined in A3 compound showing less antibacterial activity against the experimental bacteria.

Keywords: Synthesis, Identification, Schiff bases derivatives, Antimicrobial Activity.