Abstract

TRANSDERMAL DELIVERY OF STAVUDINE USING PENETRATION ENHANCERS

Jai Deo Pandey, Ritu Singh* and Nripendra Singh

Abstract

The purpose of this research work was formulation and evaluation of transdermal drug delivery system of Stavudine using suitable penetration enhancers by using solvent evaporation technique for improvement of bioavailability of drug and reducing toxic effects. Chitosan membranes were obtained by a casting/solvent method and cross-linking with sodium tripolyphosphate. The prepared formulations were evaluated for various parameters like weight, thickness, drug content, percentage moisture content, percentage moisture uptake, tensile strength, folding endurance, In vitro drug release and in vitro permeation studies. Also these patches were characterized by Scanning Electron Microscopy, Fourier transforms Infrared Spectrosphotometry, Differential Scanning Calorimeter, X-ray diffraction, skin irritation and stability. All the patches were uniform with respect to physicochemical evaluation. FTIR study and DSC analysis showed that there was no significant interaction between the drug and polymers. X-ray diffraction study indicating that drug in the matrix film is not present completely in the crystalline state, but is in the amorphous solid dispersion state. The result of diffusion study shows that formulation F10 (oleic acid) showed maximum diffusion of 89.35% in 10 h, whereas F6 (without enhancer) showed minimum diffusion of 24.81% in 10 h.The various permeation parameters were determined for all the formulations. The maximum flux was obtained with F10 formulation. All the films were found to be stable with respect to their physical parameters and drug content. Drug release kinetics has shown that formulations F6 and F10 follow first order kinetics. The n values obtained between 0.878 to 1.131 which indicates that the release approximates non fickian diffusion and case II transport. It was concluded that the results of drug permeation from transdermal patches (F10 and F9) of stavudine through excised rat

Keywords: Stavudine, Chitosan, Penetration enhancers, In- vitro evaluation.