Abstract

SURFACE SOLID DISPERSION OF DOMPERIDONE FOR DISSOLUTION RATE ENHANCEMENT

Tatapudi Naga Aparna* and Dr. Ambati Sambasiva Rao

Abstract

The main objective of the study was to enhance the dissolution rate of poorly water soluble drug Domperidone by Surface solid dispersion (SSD) technique. Water-insoluble carriers like Sodium starch glycolate (SSG), Crospovidone, Avicel PH 102, Pre-gelatinized starch, Cab – osil M5 and Florite R were used in different ratios to prepare SSD by solvent evaporation method. SSD prepared with Florite R as carrier in the ratio of 1:10 showed the highest dissolution rate as compared to pure drug. Increase in the dissolution rate may be attributed to the reduced particle size of drug deposited on the surface of carrier and enhanced wettability of the drug particles by the carrier. The optimized formulation was evaluated by X-ray diffractometry (XRD), Differential scanning colorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). These tablets, apart from fulfilling the official and other specifications, exhibited higher rates of dissolution and dissolution efficiency values compared to their commercial counter parts. Mathematical modeling of dissolution data shows fitting into first order kinetics. Accelerated stability studies performed on optimized formulation indicated no significant change in the drug content and dissolution rate.

Keywords: Domperidone, Sodium starch glycolate, Crospovidone, Surface Solid Dispersion, In-vitro dissolution, Florite R.