Abstract

ROLE OF ENDOPLASMIC RETICULUM STRESS AND UNFOLDED PROTEIN RESPONSES IN HEALTH AND DISEASE

Shilpa Rattan*, Shikhaa Mahajan, Suvarana Prasad, Sunita Manhas, Sunil Kumar, Rooma Devi

Abstract

Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response (UPR), which induces profound changes in cellular metabolism including general translation attenuation, transcriptional upregulation of molecular chaperone genes and activation of ER-associated degradation. Moreover, ER stress is involved in causing many diseases inducing apoptosis like osteoporosis, diabetes, inflammatory responses, cancer, neurodegenerative diseases (Alzheimer's disease & Parkinson's disease) etc.

Keywords: Alzheimer's disease & Parkinson's disease.