Abstract

A NEW MANNICH BASE N-[PHENYL(PYRROLIDIN-1- YL)METHYL]ACETAMIDE - SYNTHESIS, SPECTRAL PROPERTIES, ANTIBACTERIAL AND ANTIFUNGAL STUDIES OF SOME OF ITS METAL COMPLEXES

L. Muruganandam*, S. Selvam and R. Venkatachalam

Abstract

A new Mannich base ligand: N-[Phenyl(pyrrolidin-1- yl)methyl]acetamide(PBA) was prepared and characterized by elemental analysis and various spectral studies. Some metal complexes of a ligand with CoII, NiII and CuII have been synthesized and characterized by elemental analysis, molar conductance values, magnetic susceptibility measurements and various spectral studies. The spectral data reveals that the ligand acts as bidentate and tridentate coordination to the metal ion through the CNC nitrogen, carbonyl oxygen and amido nitrogen atoms. Based on the magnetic and electronic studies, all the complexes are high spin octahedral geometry. The conductance measurements indicate that the non-electrolytic nature of the complexes. The biological activities of the ligand and complexes have been screened in vitro against some bacteria and pathogenic fungi to study their capacity to inhibit their growth.

Keywords: aminomethyl, pharmacological, polycrystalline, tetragonal, distorted, liphophilic.