Abstract

IN-VITRO ANTIHISTAMINIC AND ANTISPASMODIC POTENTIAL OF METHANOLIC EXTRACT OF LEAVES OF TRIDAX PROCUMBENS LINN.

Asha Jadhav*, Ashok Muchandi, Suraj Yadav, Mayur Shekh and Priyanka Sawant

Abstract

Background: Tridax procumbens, commonly known as coatbuttons or tridax daisy, is a species of flowering plant in the daisy family. The plant bears daisy like yellow-centered white or yellow flowers with three-toothed ray florets. The leaves are toothed and generally arrowhead-shaped. Its fruit is a hard achene covered with stiff hairs and having a feathery, plume like white pappus at one end. Traditionally, Tridax procumbens has been in use in India for wound healing and as an anticoagulant, anti-inflammatory, antifungal, and insect repellent. The present study was undertaken to evaluate in-vitro antihistaminic and anti-spasmodic activity of methanolic extract of leaves of Tridax procumbens L. by using isolated goat tracheal chain and chicken ileum preparation. The cumulative concentration response to histamine and Acetyl choline in the absence and presence of methanolic extract were recorded with a kymograph. The methanolic extract decreases the goat tracheal contraction and ileum contractions induced by histamine and Acetyl choline in dose dependent manner as compared with standard drug Chlorpheniramine Maleate and Atropine Sulphate respectively. This revealed that methanolic extract of leaves of Tridax procumbens L. possess a high degree of antihistaminic and spasmolytic activity by blocking histaminic and cholinergic receptors.

Keywords: Anti-histaminic, Anti-spasmodic, Tridax procumbens, Histamine, Chlorpheniramine maleate.