Abstract

IMPACT OF THYROID DISORDERS ON SERUM ACTIVITY LEVELS OF LIVER ENZYMES, CPK AND LDH IN SUDANESE PATIENTS

Mussab Mohammed Mohammed Salih, Mariam Abbas Ibrahim*, Altaf Suleman Mosad Taaha and Tahani Osman Mohamed Alzein

Abstract

Thyroid hormones exert their effect on all tissues and modulate the rate of metabolic activity. Alterations in thyroid function can affect the various organ system of body and perturb measures like AST, ALT, ALP, GGT, CPK and LDH. Both hyperthyroidism and hypothyroidism have potentially fatal systemic manifestations. The main aim of this study was to determine the relationship between thyroid alteration and serum enzymes levels. The study included 185 subjects visiting endocrinology unit of the department of clinical chemistry; ALribat University Hospital, Khartoum, with the request of Thyroid Function Test. Thyroid profile and serum enzymes were analyzed using standard kits. Our findings showed a significant increase levels of AST, GGT, CPK and LDH and no significant difference was shown in ALT and ALP when compared to controls.In conclusion enzymes ALT, GGT, CPK and LDH increased in thyroid disorders; while AST and ALP are not affected. There is a correlation between age, gender and activity of enzymes of ALT, GGT, CPK and LDH; while no correlation were found in AST and ALP. These results could be used as diagnostic parameters for thyroid disorders.

Keywords: Thyroid disorders, TSH, T3, T4, AST, GGT, CPK and LDH, Sudan.