Abstract

PRONIOSOMES: PENETRATION ENHANCERS IN TRANSDERMAL DRUG DELIVERY SYSTEM

Jitendra R. Desai*, Jagtap R. S., Doijad R. C., Pol S. V, Pawar J. D., Jadhav V. V., Kengare V. D. and Jagtap S. R.

Abstract

The aim of the drug delivery system is deliver the therapeutic agent into the desired site of action. The transdermal route is most important but the stratum corneum acts as barrier which is present on the top of the epidermis and also acts as the rate limiting membrane of penetration of drugs. Vesicular drug delivery system such as niosomes and liposomes are promising systems to cross this permeation barrier. The provesicular niosomes is the colloid carrier in the early stage of developed it may need to exploit more in field of drug delivery. They are non-toxic and non-immunogenic bilayer that be changed to niosomes once applied to skin by absorption of water and interacts with the strong hydrogenbond of stratum corneum and loosens it, thereby permitting the diffusion of drug into the skin. The provesicular system is the new emerging concept and it provides the solution to gel of the stability and also provides the higher entrapment efficiency over conventional systems.This review provides a very important summary of preparation, formulation, characterization and application of proniosome gel as a drug carrier.

Keywords: Provesicular systems, proniosomal gel, non-ionic surfactant, penetration, entrapment efficiency, transdermal.