Abstract

ORGANOGELS IN DRUG DELIVERY SYSTEM

Dugesh kumar, Dr Sandip Prasad Tiwari and Dr Rishi Paliwal

Abstract

In the last decade, interest in physical organogels has grown rapidly with the discovery and synthesis of a very large number of diverse molecules, which can gel organic solvents at low concentrations. Organogels is a viscoelastic carrier system, can be regarded as a semisolid preparation in which an organic (apolar) liquid phase is immobilized by a three-dimensional network composed of selfassembled, intertwined gelator fibers. An organogel is a non crystalline, non-glassy, thermoreversible (thermoplastic) solid material composed of a liquid organic phase. Organogels are thermodynamically stable, biocompatible, isotropic gel, which not onl give localized effect, but also systemic effect through percutaneous absorption. Organogel can be prepared by solid fiber matrix and fluid fiber matrix method. In the current review aims at giving an idea about the properties of organogels, various types of organogelators and organogels, factors, characterization and applications and importance in drug delivery.

Keywords: Drug delivery, Non-crystalline, Organogel, Self-assembbled, Semi-solid, Thermoreversible, Three-dimentional network, Viscoelastic.