Abstract

AN OVERVIEW OF PELLETIZATION TECHNIQUES USED IN MULTIPARTICULATE DRUG DELIVERY SYSTEM

Samreen Mansoori*, Asish Dev and Saritadevi Gupta

Abstract

Pharmaceutical research are increasingly focusing on new delivery systems which enhances desired therapeutic objective and therefore minimising side effects. The multiparticulate drug delivery systems are suitable for oral formulation to achieve controlled or delayed release. It has advantages like low dose dumping, flexibility of blending to attain different release pattern and for short gastric residence time. Therefore multiparticulate drug delivery system (MPDDS) provides opportunities in designing controlled and delayed release oral formulation. Pellets are defined as spherical/ semi-spherical, free flowing solid units with a narrow size distribution, typically in diameter between 0.5-2.0 mm. Pelletization technique is used to produce pellets. Pelletization techniques include Extrusion speronization, layering, Cryopelletization, freeze pelletization, spray congealing, spray drying and compression. Extrusion sheronization is widely used technique due to high efficiency and fast and simple processing.

Keywords: Multiparticulate system, Pellets, Pelletization, Extrusion-speronization, Cryopelletization, Spray Congealing.