Abstract

ENHANCEMENT OF SOLUBILITY OF TELMISARTAN USING VARIOUS METHODS AND CARRIERS

P. K. Lakshmi*, Deepthi Goud N. and Kalyani N.

Abstract

The aim of this study was to enhance the solubility of telmisartan for which solid dispersions with different carriers were prepared by hydrotropy, physical mixture and solvent evaporation method. The interaction studies of solid dispersions showed no interaction between the drug and the carrier. Hydrotropic solid dispersions prepared with urea showed enhancement in solubility by l7.42 folds and 99.14±0.69% release in 60 minutes in distilled water. The physical mixture of telmisartan and cross povidone showed enhancement in solubility by 9.71 folds and 68.38±1.47% release in 60 min in distilled water. The solvent evaporation method showed an increase in solubility by 12.28 folds and 99.76±1.95 % release in 60 minutes in distilled water and 99.78% release in 45 min in 0.1N HCL. The hydrotropic agent, urea was successful in improving the dissolution rate of telmisartan by hydrotropy method and crosspovidone improved the dissolution rate of telmisartan by solvent evaporation method.

Keywords: Solid dispersion, solubility, carrier, hydrotropy.