Abstract

INVITRO ANTI- INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF APOROSA LINDLEYANA LEAVES

Aswathi V.*, Kavitha G., Greshma John., Sreedevi R. and Elessy Abraham

Abstract

Aporosa lindleyana is a plant belonging to the family Euphorbiaceae, grows as small middle sized tree up to 15 m height, found throughout India. In the indigenous system of medicine the plant Aporosa lindleyana leaves have been claimed to be diuretic, roots to be used in insanity, head ache, fever, diabetes, loss of semen and liver diseases.[1] Traditionally, it is widely used in the treatment of inflammation and related disorders. However there is no scientific report available on its anti-inflammatory activity. Hence, the present study was designed to investigate the anti-inflammatory activity of ethanolic extracts of Aporosa lindleyana leaves by in vitro method. The preliminary phytochemical analysis of ethanolic extract showed the presence of many biologically active phytochemicals such as flavonoids, alkaloids, phenolic compounds, saponins, steroids and tannins and these compounds might be responsible for the anti-inflammatory properties. The possible antiinflammatory mechanism of the Aporosa lindleyana leaf extract may be through its free radical scavenging activity, its hydrogen donating ability and increase antioxidants levels. Thereby, ethanolic leaf extract of Aporosa lindleyana preventing the spread of inflammation.

Keywords: Aporosa lindleyana, alsevers solutions, DPPH assay.