Abstract

ROLE OF MATRIX TABLET IN SUSTAINED RELEASE SYSTEM

Saritadevi Gupta*, Asish Dev, Samreen Mansoori and Akshay Yelwe

Abstract

Many of the pharmaceutical dosage form are formulated as sustained release dosage form to retard the release of therapeutic agent such that its appearance in systematic circulation is prolonged and plasma profile is sustained in duration. Matrix system is widely used for purpose of sustained release. Developing oral sustained release matrix tablet with constant release rate has always been a challenge to pharmaceutical technologist. matrix tablet may be formulated by wet granulation or direct compression method by dispensing solid particle with in a porous matrix formed of hydrophilic and hydrophobic polymers. Hydrophilic polymers have become product of choice as an important ingredient for formulating sustained release formulation.

Keywords: sustained released, matrix tablet, direct compression, wet granulation, hydrophilic and hydrophobic polymers.