Abstract

SYNTHESIS AND ANTI INFLAMMATORY ACTIVITY OF 3,5- DIPHENYL 4-AMINO 1,2,4 -TRIAZOLE DERIVATIVES

Gajanan Sanglikar*, Sandyavalli M. S., Manjunath E. and Kavitha N. V.

Abstract

Compounds with 1, 2, 4-triazole moiety found to display a wide range of potent biological activities such as antifungal, anti-inflammatory, anticonvulsant, antimicrobial and anti tumor activity. In the present scheme, we have made an attempt to synthesize some novel triazole derivatives by reacting 3, 5-diphenyl, 4-amino triazole with various aromatic aldehydes to get Schiff’s bases (comp I). Compound I is further reduced with NaBH4 to get the reduced intermediate (comp II), which was later treated with chloroacetyl chloride to get corresponding chloro acetyl derivatives (comp III). The resulting compound is further reacted with hydrazine hydrate. The hydrazine hydrate derivatives were then reacted with 4-nitrobenzaldehyde to get titled compounds. The synthesized compounds were characterized and confirmed by IR and NMR spectroscopy.

Keywords: 4-Amino triazole, Schiff’s base, NaBH4, Hydrazine hydrate.