Abstract

A CROSS SECTIONAL STUDY IN NORTH EASTERN UTTAR PRADESH POPULATION FOR THE ESTIMATION OF BMI, HDL & TRIGLYCERIDES LEVELS IN RECENTLY DIAGNOSED PATIENTS WITH TYPE 2 DIABETES MELLITUS TAKING METFORMIN ALONE, METFORMIN WITH ADD ON SITAGLIPTIN AND SITAGLIPTIN

*Neerjesh, Vipender Singh Chopra, Raj Kishore Singh, Rakesh Chandra Verma, Praduman Mall and Gyanendra Kumar Bind

Abstract

Objectives: To evaluate the role of Metformin, Sitagliptin & combination of both drugs in Body weight, HDL-C & Triglyceride levels in recently diagnosed patients of type 2 Diabetes mellitus. Methods: This cross-sectional study includes analysis of total 75 patients divided in 3 groups. Metformin group (2000 mgs), Sitagliptin group (100 mgs), Combination of both Metformin & Sitagliptin group (Metformin 1000 mg+ Sitagliptin 50 mg). Their body weight (BMI) & Laboratory investigations regarding HDL & Triglycerides were carried out and findings were noted in each follow-ups. Results: After 24 week onwards there were statistically significant reduction in BMI in each group but the in 3rd group (Combination group) the reduction in BMI was Most highly significant (p<0.001). On other hand HDL level was raised significantly (p<0.01) in all the three groups but in the Sitagliptin and combined group it was most highly significant (p<0.001) observed from 24 week onwards, whereas in Triglyceride levels, Metformin and Sitagliptin, both group of patients showed significant (p<0.01) reduction. Metformin group showed significant (p<0.01) reduction earlier at 12 week and Sitagliptin showed significant reduction (p<0.01) later at 36 week. In the combined group it was insignificantly (p>0.05) fluctuating. Conclusions: In conclusion, significant differences was found in effects of Sitagliptin treatment on body weight (BMI) & HDL, Triglycerides level in patients recently diagnosed with type 2 Diabetes mellitus.

Keywords: Type 2 diabetes mellitus, Body weight, HDL-C, Triglycerides, Metformin, Sitagliptin.