Abstract

A COMPARATIVE STUDY ON THE EFFECT OF HMG-CoA REDUCTASE INHIBITORS ON C-REACTIVE PROTEIN IN PATIENTS WITH ACUTE CORONARY SYNDROME

Mathew George, Lincy Joseph, Bincy.K.Chacko and Jess Jose

Abstract

Objectives: The objectives of the study is to compare the effect of HMG-CoA reductase inhibitors (Atorvastatin 80mg and Rosuvastatin 40mg ) on hs-CRP, to evaluate the clinical outcome of the of HMGCoA reductase inhibitors and to document the adverse drug reaction (ADR) of HMG-CoA reductase inhibitors in patients with Acute Coronary Syndrome. Methods: This is a prospective experimental study conducted in 60 inpatients diagnosed with Acute Coronary Syndrome. The study population was divided into two groups. In each group, 30 patients were enrolled. One group included the patients who were taking Atorvastatin 80mg and the second group with Rosuvastatin 40mg. The hs-CRP levels, lipid profiles and adverse effects were measured at beginning and at the end of 2 weeks. Results: The HMG-CoA reductase inhibitors, atorvastatin 80mg and rosuvastatin 40mg reduces the hs-CRP levels significantly. Both atorvastatin and rosuvastatin have significant effect on lipid profile. There is significant difference in effect of atorvastatin and rosuvastatin in lowering of hs-CRP levels (P

Keywords: Acute Coronary Syndrome, HMG-CoA reductase inhibitors, Atorvastatin, Rosuvastatin, C - Reactive Protein (CRP), High-Sensitivity C-Reactive Protein (hs-CRP).