Abstract

COMPARATIVE STUDY OF ANTI-INFLAMMATORY ACTIVITY OF WITHANIA SOMNIFERA WITH ASPIRIN IN EXPERIMENTAL ANIMALS (ALBINO RATS)

Dr. Kiran R. Giri, *Dr. Kamlesh M. Palandurkar and Dr. Reena R. Giri

Abstract

The roots of Withania somnifera consist primarily of compoundsknown as withanolides A & D, which are believed to account for itsextraordinary medicinal properties. Objective of the study is tocompare the anti-inflammatory effect of Withania somnifera &NSAIDs (Aspirin). Acute inflammation was produced by sub-plantarinjection of 0.1 ml of 1% freshly prepared solution. The groupsconsisted of complete Freund’s adjuvant (CFA)- 0.1ml injected ratschallenged with doses of the test drug and standard drug administeredorally 2 h before induction of arthritis. In our study we used 100mg/kgAspirin as a standard drug for evaluation of anti-inflammatory activity.In present acute study, % inhibition of paw oedema was found to be63.64% with aspirin as compare to 61.36% with Withania somnifera atthe end 3hrs.

Keywords: Withania somnifera, Anti-inflammatory activity, Aspirin.