Abstract

POTENT ANTIDIABETIC ACTIVITY OF AQUEOUS EXTRACT OF BROWN SEAWEED PADINA BOERGESENII IN STREPTOZOTOCININDUCED DIABETIC RATS

Senthilkumar P.*, Ranjith Santhosh Kumar D. S., Surendral L., Sudahar B., Nazir Hazza Abdul Karim Taha, Harshini J. and Sathya Priya N.

Abstract

Identification of new drugs from marine has major focus of researchers. In the present study, the effect of aqueous extract of brown algae Padina boergesenii in streptozotocin (STZ) induced diabetic rats. Diabetes mellitus was induced by a single intraperitoneal injection of STZ (60 mg/kg bw). Oral administration of the effective dose of P. boergesenii to the diabetic rats for 20 days showed abridged effects on protein, hemoglobin and glycosylated hemoglobin levels. Significant difference was observed serum urea, uric acid and creatinine levels in diabetic rats after P. boergesenii extract treatment (p

Keywords: Seaweed, aqueous extract, Padina boergesenii, antidiabetic activity, Streptozotocin.