Abstract

FORMULATION AND INVITRO EVALUATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM

Azeez Mohammad*, Potlapally Laxmi, S. Swathi and G. Shirisha

Abstract

The present Researchwork was aimed at enhancing the solubility of Candesartan cilexetil by formulating SEDDS (self-emulsifying drug delivery system) evaluating its in vitro potential. The solubility of Candesartan cilexetil was determined in various vehicles. Various combinations of oils (arachis oil, Sunflower oil, coconut oil and soybean oil), surfactant (Cremophor Rh 40), and co-surfactant (polyethylene glycol 400) were used to formulate SEDDS. Pseudo ternary phase diagram was used to evaluate the effective emulsification area. SEDDS formulations were tested for emulsifying properties and the resultant emulsions were evaluated for clarity, precipitation, particle size distribution and drug release studies. Optimization of the formula and screening was done based on characteristics of resultant emulsions. The optimized formulation composed of soybean oil (45%), Cremophor Rh 40 (50%), and polyethylene glycol 400 (05%) and showed complete drug release in 60 minutes which was far better than that of plain drug.

Keywords: Candesartan cilexetil, SEDDS, pseudo ternary phase diagrams, angiotensinreceptor blocker, BCS class II drug.