Abstract

RECENT ADVANCES AND PATENTS OCULAR DRUG DELIVERY SYSTEM

Neha* and Mohamed Yasir 

Abstract

Background- A wide variety of drug delivery system have been developed to treat the disease of eye. Some traditional ocular drug delivery system is used but it has some disadvantages is to eliminate from the anterior part of eye and lack of retention time of contact with eye due to specific anatomy and physiology barrier of eye. Objective- The main objective of the study to review the recent advance and patent nanoformulation for ocular drug delivery system. as well as various therapies which are targeted into gene and protein of anterior part of eye to treat the genetic disorder of eye with specific rout of administration. Result- Recently advance ocular drug delivery system have been developed to produced controlled drug release into eye segments. The most powerful advantage of recent drug delivery system over the traditional drug system is to increase solubility of poor soluble drugs into eye and cross the various barrier of the eye to reached the anterior parts as well as posterior parts of eyes. Conclusion- FDA website described that only 21 ocular drugs were approved in the last 10 years; 30 new drugs last back to 1995. No ocular drugs were approved in 1995 or 2003. It is proved that efficiency of nanoparticles for ocular drug delivery is much better than other novel drug delivery systems in terms of dose, stability, cell targeting, particle size etc. Nanohydrogel, lipid nanoparticles, nanosuspension, etc. are being used successfully in ocular nanotechnology.

Keywords: Drug delivery, nanoemulsion, liposome, microemulsion, glaucoma, Nanotechnology, Patent.