Abstract

A COMPARATIVE STUDY ON THE SAFETY AND EFFICACY OF METFORMIN MONOTHERAPY AND METFORMIN-GLIMEPIRIDE COMBINATION THERAPY IN PATIENTS WITH TYPE-II DIABETES MELLITUS

Mina Bhatta*, Amrit Khanal, Hari Prasad Sapkota and Poonam Shah

Abstract

Aim: The aim of the study was to comparatively evaluate the efficacy of Metformin and Metformin-Glimepiride on glycemic control in patients with type-II Diabetes Mellitus. Methodology: A total of 184 subjects were included in the study and equally divided in to 2 groups of 92 subjects each i.e. monotherapy group and combination therapy group. The blood glucose level of subjects consecutively for three visits was recorded during two course of drugs intake with an interval of 2 weeks in between. Results: The fasting blood glucose and Post prandial blood glucose patients before and after monotherapy was 157.99±49.00, 248.60±80.8 and 128.95±35.3, 201.89±62.6. Similarly in combination therapy the fasting blood glucose and post prandial blood glucose before and after treatment was 169.13±43.9, 275.2±74 and 161.36±37.4, 247±39.37. Conclusion: Combination therapy with Metformin and Glimepiride has resulted in greater reduction of FBGL (P=0.021) in fasting condition and Metformin monotherapy has proven beneficial in lowering PPBGL (P=0.0013) in after food condition.

Keywords: Metformin, Glimepiride, Hyperglycaemia, Blood Glucose Levels.