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Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF IRBESARTAN AND ATORVASTATIN CALCIUM.

Gangaram B. Kale* and Dr. S. Z. Chemate

Abstract

Fast Dissolving Tablets (FDT)) are most accepted and exploited drug delivery for the patients who are having difficulty with swallowing i.e., mainly and Geriatric’s. Irbesartan (IRB) is an anti-hypertensive and it is also used in many Coronary artery diseases, Where As Atorvastatin Calcium (ASC) is an anti-hyperlipidemic that prevents of Atheroma. The aim of the paper was to formulate a combined oral dosage form of Irbesartan and Atorvastatin calcium into fast dissolving tablet using three super disintegrants such as Croscarmellose Sodium (CCS), Crosspovidone (CP), Sodium Starch Glycolate (SSG) at various concentrations to enhance the disintegration and dissolution of IRB and ASC to improve bioavailability of the drugs. The tablets were prepared by using direct compression method and evaluated for weight variations, Hardness, Friability, Wetting time, Disintegration time and Dissolution study. Prepared tablets are subject to FT-IR Study for Characterization and compatibility study. No Chemical interaction between drug and excipients were indicated in the FT-IR. Disintegration and dissolution profiles decreases with addition of super disintegrating agents like Croscarmellose Sodium (CCS), Cross povidone (CP), Sodium Starch Glycolate (SSG). Among all the formulation F6 with CP in 5% Concentration found to be best in drug release profile. The results showed that superdisintegrants used in single shows better disintegrating property. Among all formulations, promising formulation F6 showed good wetting time (40 sec), fastest disintegration time (52 sec) and maximum drug release of 95.66%(ASC) and 89.24%(IRB) within 45 minutes.

Keywords: Irbesartan, Atorvastatin, Antihypertensive, Antihyperlipidemic, Wetting time.


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