Abstract

MITIGATION OF EARLY DELTAMETHRIN INDUCED HEPATOTOXICITY IN MALE MICE OF SWISS STRAIN BY ALLIUM SATIVUM

Prof. Ketaki R. Desai, Dr. Nilofar Moid, Nihar K. Nimbark, Prof. Dr. Hyacinth N. Highland*

Abstract

The importance of Allium sativum as herbal remedy in the system of Indian traditional medicine and its prime position in Ayurveda with other great herbs is unquestionable. Though extensive research has been carried out by number of researchers on its medicinal properties, there is still paucity regarding its ameliorative efficacy. Hence, the present study focuses to evaluate the potential ameliorative effects of Allium sativum (AS) against Deltamethrin (DLM) induced toxicity in hepatic tissues of male mice of Swiss strain (Mus musculus). Animals were divided into seven different experimental groups viz. Control, Vehicle treated (peanut oil), DLM low dose treated (3 mg/kg b.wt.), DLM high dose treated (6 mg/kg b.wt), control + AS, DLM low dose + AS and DLM high dose + AS. Various bio-chemical indices and gravimetric parameters were assessed at durations of 14 and 21 days. Results revealed that in experimental (DLM treated) groups parameters like total body weight, liver weight, protein content as well as the activity of enzymes like SDH, ALKpase, ACPase and ATPase were found to be reduced in a dose and duration dependent manner, whereas cholesterol level in the hepatic tissue was found to be elevated. Moreover, these altered parameters were significantly recovered when AS (200mg/kg body weight) was supplemented along with DLM and the observed recovery was comparable to control values.

Keywords: Deltamethrin, Allium sativum, Hepatotoxicity, Amelioration.