Abstract

CROSS-SECTIONAL STUDY IN NORTH EASTERN UTTAR PRADESH POPULATION FOR THE ASSESSMENT OF BETA CELL FUNCTIONS IN PATIENTS WITH RECENTLY DIAGNOSED TYPE 2 DIABETES MELLITUS TREATED WITH METFORMIN ALONE, METFORMIN WITH ADD ON SITAGLIPTIN & SITAGLIPTIN ALONE

Dr. Neerjesh*, Raj Kishore Singh, Vipender Singh Chopra, Akash Gajjar, O.N.Pandey and Praduman Mall

Abstract

To assess the utility of Metformin & Sitagliptin alone overcombination of Metformin and Sitagliptin on function of β cells inpancreas in patients with recently diagnosed type 2 Diabetes Mellitus.Methods- This cross-sectional study includes analysis of total 75patients who were divided in 3 groups. Metformin (2000mgs) group,Sitagliptin (100 mgs) group, Combination group (Metformin 1000mg+ Sitagliptin 50 mg). Various laboratory investigations were carriedout in all the subjects and findings were noted. Results- The highlysignificant reduction (p<0.01) in Mean HbA1c in combined group ofMetformin and Sitagliptin as well as significant reduction in otherparameters for measuring blood Sugar in all the three groups (p<0.05)were noted. Conclusions- These results suggest that the actions of DPP-4 inhibitors i.e.Sitagliptin in combination with Metformin improve glycemic control as well as quality of life(QOL).

Keywords: DPP-4 inhibitor, Metformin, Type 2 Diabetes mellitus, Beta cell function assessment.