Abstract

DIABETIC NEUROPATHY: LATEST CONCEPTS

Somnath Kharwar*, Md. Quamuddin, Abhay Kumar Verma, Sonia Chauhan

Abstract

Neuropathy, a common complication of diabetes mellitus, is generally considered to be related to duration and severity of hyperglycaemia one of the largest published series reported a prevalence of 7.5% even at the time of diagnosis of diabetes. The prevalence however, increases progressively without a plateau. Distal symmetrical sensori-motor polyneuropathy: It is the most common type of diabetic neuropathy. It involves both small and large fibres and has insidious onset. Typically, the most distal parts of the extremities are affected first, resulting in a stocking pattern of sensory loss. The agents used for nerve regeneration are known as neurotrophic factors. The neurotrophic factor is defined as a naturally occurring protein that is released by target tissues of responsive neurons, binds to specific receptors and is retrogradely transported to the cell body where it regulates gene expression through the actions of second messenger systems.

Keywords: Nerve Regeneration, Hyperglycaemia, Fiber, Diabetic Neuropathy, Neurotropic Factor.