Abstract

RECENT TRENDS IN GASTRORETENTIVE FLOATING DRUG DELIVERY SYSTEM-A REVIEW

Rukhsar Khan, Anup Ojha, Ritika Arora, Kumud Upadhyay* and Himansu Chopra

Abstract

Gastro retentive drug delivery system have been a significant approach over the past few years to prolong gastric residence time, thereby targeting site-specific drug release in the upper gastrointestinal tract for local or systemic effect. Conventional oral dosage forms having low bioavailability problems due to their rapid gastric transition from stomach, in case of drugs which are less soluble at alkaline pH of intestine. Further drugs which produce their local action in stomach, get rapidly emptied do not get enough residence time in stomach. Hence, the frequency of dose administration in such cases is increased. To avoid these problems, various efforts have been made to prolong the retention time of drug in stomach. Floating system has been considered as imperative categories of drug delivery system which has gastric retentive behaviour. FDDS is lowdensity systems that have sufficient buoyancy to float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The review article explain the various floating drug delivery system that are formulated in order to enhance the drug bioavailability, reduce drug wastage & provide controlled drug delivery & better patient compliant. Several approaches & techniques were developed in recent years for FDDS are discussed.

Keywords: Floating Drug delivery system, Gastro retentive.