Abstract

ASSOCIATION OF LIVER AND RENAL FUNCTION AND THE TREATMENT OF HYPERTRIGLYCERIDEMIA IN DIABETES PATIENTS

T. Abdu Rahman*, A. Anil Babu and K. Anoop Kumar

Abstract

The incidence and prevalence of diabetes mellitus have grown significantly throughout the world. The prevalence rate of hypertriglyceridemia in diabetic population is high and is correlated with liver function and renal function parameters. Overall increase in the number of people with diabetes has had a major impact on the development of diabetic kidney disease, which is the leading cause of end-stage renal disease. In individuals who have diabetes type 2, there is a higher incidence of liver function abnormalities than individuals who do not have diabetes. Coronary heart disease is the leading cause of death among type 2 diabetic patients. Much of the increased disease is associated with a well characterized risk factor for coronary heart disease like lipids and lipoprotein abnormalities. The role of triglyceride levels in determining diabetic risk was proved and is considered as a sensitive biomarker for lifestyle habits related to the risk of developing diabetes, therefore diabetes and triglycerides are well associated. Pharmacological management of hypertriglyceridemia among diabetic patients varies with their triglyceride levels. The combination of elevated triglycerides, low high density lipoprotein cholesterol and relatively normal low density lipoprotein cholesterol carried in small, dense, cholesterolpoor low density lipoprotein particles, has been called diabetic dyslipidemia. This form of dyslipidemia does not respond well to statin therapy. Hence, the need for additional or alternative therapy is inevitable. This study will help in the management of hypertriglyceridemia in diabetes mellitus patients and improving health care by routine monitoring.

Keywords: Type 2 Diabetes, Coronary Heart Disease, Diabetic Kidney Disease, End Stage Renal Disease, Diabetic Dyslipidemia.