Abstract

EFFECT OF ETHANOL EXTRACT OF SEED OF MUCUNA PRURIENS ON GASTRIC ULCERS

Har Govind Garg*, Ashish Chourasiya and Dr. H. S. Chandel

Abstract

The present study was carried out to evaluate the effect of ethanol extract of seed of Mucuna pruriens (0.5 g/kg, p.o. and 1 g/kg, p.o.) on gastric ulcers. The study was carried out on different gastric ulcer models such as pylorus ligation, indomethacin induced ulcers and stress induced ulcers. Ranitidine (50 mg/kg p.o.) and misoprostol (100 μg/kg, p.o.) were used as standard drugs. Both doses of ethanol extract of seed of Mucuna pruriens showed gastric ulcer healing effect and gastric antisecretory effect in pylorus-ligated rats and also showed gastric cytoprotective effect in indomethacin-induced ulcer and also produced a significant reduction in the development of stress induced gastric ulcers. The high dose of ethanol extract of seed of Mucuna pruriens (1 g/kg, p.o.) was more effective compared to the low dose (0.5 g/kg, p.o.). Ethanol extract of seed of Mucuna pruriens showed gastric antisecretory and cytoprotective effect and prevents the development of experimentally induced gastric ulcers in rats.

Keywords: Mucuna pruriens, gastric ulcers, gastric antisecretory, gastric cytoprotection.