Abstract

FORMULATION AND EVALUATION OF LEVOCETERIZINE HYDROCHLORIDE TRANSDERMAL PATCHES.

Gorakshanath E. Bhokare* and Dr. S. Z. Chemate

Abstract

Transdermal drug delivery system is a therapeutic system designed to transfer drugs through intact skin for systemic treatment. It offers controlled drug release pattern by a simple application to the skin's surface, eliminating the vagaries influencing the gastrointestinal absorption associated with oral administration and providing for more efficient drug utilization. Levoceterizine hydrochloride belongs to the category of anti histamine used in the treatment of various allergic diseases. Administration of these agent via transdermal route can bypass various disadvantages caused by oral administration and maintain relatively constatant plasma drug level for long time therapy. Different polymers Different polymers like hydroxypropylmethyl cellulose (HPMC), polyvinyl pyrrolidine (PVP) individually or in combination have been tried. All the patches were prepared by adding glycerin as plasticizer. Methanol is used as a common solvent. The prepared patches were evaluated for physicochemical parameters like thickness, weight variation, folding endurance, water absorption capacity, moisture content, tensile strength, percentage elongation, drug content.

Keywords: Levoceterizine Hydrochloride, polymers, Transdermal drug delivery system.