Abstract

EFFECT OF BULK DENSITY ON TENSILE STRENGTH OF TABLETS PREPARED BY USING HICELTMMCC (MICROCRYSTALLINE CELLULOSE) AND HICELTMSMCC (SILICIFIED MICROCRYSTALLINE CELLULOSE)

Jilika Shah*, Monika Tomar, Ajay Kumar Singh and Amit Raj Sinha

Abstract

Direct compression is an admired method for manufacturing the solid dosages form tablets. Now a days many excipients are used to manufacture the tablets. Physical parameters (bulk density, Particle size, moisture content, Carr’s index and angle of repose) and degree of polymerization are very important to manufacture tablets by direct compression. Out of this bulk density plays a vital role in direct compression method. It affects tensile strength of tablets. Tensile strength of tablet also depends on wood pulp sources, it varies from pulp-to-pulp. In this research work, we have used HiCelTMMCC 90M (Microcrystalline Cellulose) and HiCelTMSMCC 90M (Silicified Microcrystalline Cellulose) grade containing dissolving wood pulp. HiCelTMSMCC is a coprocessed excipient. It is having superior flowability and 25-30% better compaction than HiCelTMMCC. It gives very good tablet profile in terms of tensile strength, friability, disintegration time and dissolution time. The main objective of this study is to find the correlation between bulk density of HiCelTMMCC and HiCelTMSMCC and tensile strength and second correlation between tensile strength and friability of their tablets. In this study, we will make tablets using different bulk density samples of HiCelTMMCC 90M and HiCelTMSMCC 90M grade and without adding pharmaceutical active ingredient, after that evaluate quality parameter of tablet.

Keywords: Excipients, HiCelTMMCC 90M (Microcrystalline Cellulose), HiCelTMSMCC 90M (Silicified Microcrystalline Cellulose), Bulk density, Tensile strength and Friability.