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Abstract

FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF OXCARBAZEPINE

Aglawe S. B.*, Gayke A. U., Sancheti V. P. and Metkar P. S.

Abstract

The concept of Mouth Dissolving Drug Delivery System emerged from the desire to provide patient with conventional mean of taking their medication. Oxcarbazepine is an anticonvulsant drug, mainly used as an add-on or first line treatment in adults and children. Due to sudden onset of attack, it is necessary to formulate antiepileptics into such a delivery system, which provide immediate relief. Hence, the present investigation was undertaken with a view to develop mouthdissolving tablets of oxcarbazepine, which offers a new range of product having desired characteristics and intended benefits. In this study, the mouth dissolving tablets were prepared. A mouth dissolving tablet was prepared by using superdisintegrants viz; crospovidone, croscarmellose sodium and sodium starch glycolate All the batches are prepared by direct compression method. Effect of disintegrants concentration on the disintegration behavior was evaluated, and all the tablets were evaluated for hardness, friability, weight variation, water absorption ratio, dissolution, and assay. Among the all preparations F8 emerged as the best formulation and showed maximum dissolution rate.

Keywords: Mouth dissolving tablet, Oxcarbazepine, Direct compression, Superdisintegrant.


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