Abstract

FORMULATION AND EVALUATION OF AZITHROMYCIN MICROSPHERES

Kondru Lalitha*, Dr. T. Satyanarayana, I. Sharmila, G. Annapurna, S. Siva Ganesh,
B. Jyothi

Abstract

In the present work, bioadhesive microspheres of Azithromycin using Sodium alginate along with Carbopol 934, HPMC K4M as copolymers were formulated to deliver Azithromycin via oral route. The results of this investigation indicate that solvent removal cross linking method can be successfully employed to fabricate Azithromycin microspheres. The technique provides characteristic advantage over conventional microspheres method, which involves an “all-aqueous” system, avoids residual solvents in microspheres. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers and copolymers used. Micromeritic studies revealed that the mean particle size of the prepared microspheres and bulk density and tapped density were conducted are suitable for bioadhesive microspheres for oral administration. The in-vitro mucoadhesive study of Azithromycin using sodium alginate along with Carbopol 934 and HPMC K4M as copolymer was performed. The invitro drug release increased with increase in the polymer and copolymer concentration. The invitro drug release of optimized formulation is compared with marketed formulation and optimized formulation exhibited good drug release. Stability studies of microspheres were conducted for 1 weak 1 month and 2months. Analysis of drug release mechanism showed that the drug release from the formulations followed non-Fickian diffusion And the best fit model was found to be Korsmeyer-Peppas. Based on the results of evaluation tests formulation coded T4 was concluded as best formulation.

Keywords: Azithromycin, Carbopol, Microspheres, Copolymers.