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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

NEW RP-HPLC METHOD DEVELOPMENT OF ESOMEPRAZOLE AND DOMPERIDONE IN COMBINED CAPSULE DOSAGE FORM

Sarbudeen M.*, Dr. Ashok Kumar D., Bhadru B., Nettekallu Kumar Y., Mustaq Md. Rambabu B. and Pallavi N.

Abstract

A Simple, precise and robust method for estimation of Esomeprazole and Domperidone in combined capsule dosage form. The optimum mobile phase contain Sodium dihydrogen phosphate: Methanol (80: 20 V/V). Esomeprazole and Domperidone showed linearity in the range of 32 - 96 μg/ml and 24-72 μg/ml respectively. Recovery studies were carried out at 50%, 100%, 150% level and the amount recovered 101%, 98%, 99% respectively. The stability of the sample spiked with drug was subjected to short term stability at room temperature (Initial & after 8 hours) and the stability of the respective solution was determined.

Keywords: Estimation, Domperidone, Esomeprazole, RP-HPLC.

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