Abstract

EFFECT OF SILVER NANOPARTICLES ON LEVELS OF SERUM FSH, LH AND ESTRADIOL IN PCO-INDUCED FEMALE MICE

Prof. Dr. Muhammed-Baqir M-R. Fakhrildin, Lec. Assis. Suzan I. Bajilan* and Prof. Assis. Dr. Gazwa Al-Naqeeb

Abstract

This study was conducted to investigate the effect of two concentrations (0.5 and 1ppm) of silver nanoparticles on levels of serum FSH, LH and E2 in PCO-induced female mice. A number(n=80) of mature female mice were intraperitoneally injected with human Chorionic Gonadotropin (hCG) at a dose of (10 IU/ mL) three days a week for two weeks in order to induce PCO. Then, these mice were divided into two groups, according to the duration of treatment (30, 45 days). Each group was subdivided to subgroups according to the substance administrated. Two subgroups were treated with (0.5 and 1ppm) of silver NPs solution by (i.p) injection twice a week and the third subgroup was treated with metformin at a dose of (1mg/day) orally three days a week. Results: there was a significant reduction (P 0.05) were observed in serum levels of LH or E2 between groups of the (30 days) duration as compared to their similar groups of the second duration (45 days). Conclusion: There were significant alterations in levels of serum FSH, LH and E2 in the PCO-induced mice treated with both concentrations of silver NPs as compared to the control.

Keywords: Polycystic Ovary (PCO), Silver NPs, Metformin.