INVESTIGATION INTO THE ANTI-ULCER ACTIVITY OF THE METHANOL EXTRACT OF STEMONOCOLEUS MICRANTHUS HARMS, BARK (FAM: LEGUMINOSEAE)
Ezea, C.C*; C.T. Nnamdi-Okenwa, C.O. Ezugwu, F.C. Anowi,S.C. Ezea.
Abstract
The objective of this study was to investigate the anti-ulcer activity of
methanolic extract of Stemonocoleus micranthus Harms, Bark
(Leguminoseae) in rats. Fresh dried barks of Stemonocoleus
micranthus were extracted by cold maceration technique with
methanol as the solvent and the yield was concentrated on a rotary
evaporator. Anti-ulcer effects of the methanolic extract at 25, 50 and
100 mg/kg were evaluated in rats using indomethancin induced ulcer
model. Phytochemical analysis and lethality tests (LD50) were carried
out using standard methods. Results showed that the methanolic extract
exhibited significant (P
Keywords: Anti-ulcer activity, S. micranthus stem bark, phytochemical analysis.
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