ANALYTICAL METHODS FOR THE DETERMINATION OF LEFLUNOMIDE - A SHORT REVIEW
Shah Kruti V.*, Chauhan Sanjay P., Suhagia B. N.
Abstract
Leflunomide is a pyrimidine synthesis inhibitor belonging to the
(DMARD) class of drugs, used to treat the symptoms of rheumatoid
arthritis. It also helps to reduce joint damage and improves physical
functioning and to slow the progression of structural damage
associated with the disease. The substance is sold under the brand
name Arava® by Sanofi-Aventis. Arava® was approved by the U.S.
Food and Drug Administration (FDA) and by many other countries
(e.g., Canada, Europe) in 1998.A widespread review of the literature
published in various pharmaceutical journals has been conducted and
the instrumental analytical methods which are developed and used for
determination ofLeflunomide have been reviewed. This review includes UV-Visible
Spectroscopy, RP-HPLC-UV, LC-MS/MS, LC-ESI-MS/MS and UPLC-PDA. The
applications of these methods for the determination of Leflunomide in pharmaceutical
formulations and biological sample have also been discussed in this article.
Keywords: Leflunomide; Teriflunomide (A771726)
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