Abstract

STUDY OF PRELIMINARY PHYTOCHEMICAL ANTI-DIABETIC PROPERTY OF CLEOME GYNANDRA

Sangameswaran B., Venkataraman S.*, ShriShastikaa S., Sudhakaran S., Suganya E., Sureshkumarand S. and Vasavi P.

Abstract

In present times, growing and increasing interest in herbal medicines, consequently herbal medicines have established greater attention as an alternative to clinical therapy leading to increasing demand. The exclusive use of herbal drugs, prepared and dispensed by unscientifically trained herbalists, for treatment of diseases is very common in some rural communities. Cleome gynandra. Linn of Cleomaceae (Capparaceae) family is an annual herb, popular in the Ayurveda, Siddha systems of medicine. Cleome gynandra is an abundantly available species and grows as a weed in common barren land and in crop fields throughout India. The aim of this study is to determine the phytochemical constituents of Ethanol extracts of Cleome gyandra (EECG) and aqueous extract of Cleome gyandra (AECG), Phytochemical screening of whole plant crude extracts of Cleome gynandra in solvents like ethanol, aqueous extract. The quantitative studies revealed that whole plant of Cleome gynandra possessed alkaloids, carbohydrates, glycosides, saponins, phytosterols, proteins, flavonoids and lignin. The in vitro α-amylase and α- glucosidase inhibitory studies established EECG and AECG had inhibitory activity of intestinal digestive enzyme. The α-amylase inhibitor may be valued as novel therapeutic dietetic agents. Hence EECG was potent inhibition of α-amylase and α- glucosidase intestinal digestive enzyme; it may be the beneficial effect of the type 2 diabetes. The present study concludes that the leaves of Cleome gynandra can be utilized as an alternative source of useful drugs. This study justifies the use of Cleome gynandra in the treatment of ailments like diabetic mellitus.

Keywords: EECG (Ethanol extracts of Cleome gyandra), Aqueous Extract of Cleome Gyandra (AECG), ?-amylase.