Abstract

DEVELOPMENT AND EVALUATION OF PARACETAMOL SUPPOSITORIES

Tara Chand Khatri*

Abstract

Suppositories are supposed to be efficient and effective dosage formspecially to dispense analgesics and antipyretics. Paracetamol is widelyused as antipyretic and analgesic. When used in the form ofsuppositories it produces rapid effects due to its quick absorptionthrough the rectal route. During the present study, Paracetamolsuppositories are formulated by using different ratios of PolyethyleneGlycol 1000 and polyethylene Glycol 4000. The in vitro drug releaserate studies were carried out by using B.P dissolution apparatus. Theaverage weight variation of different ratios of Paracetamolsuppositories are; 2.5168 gm for the ratio of (3.35-0.65), 2.5193 gm forthe ratio of (3.00-1.00), 2.5308 gm for the ratio of (2.00-2.00), 2.5378gm for the ratio of (1:00-3.00), 1.83 gm for marketed suppository (Napa). The averagehardness of different ratios of Paracetamol suppositories are; 6.67 kg for the ratio of (3.35-0.65), 7.21 kg for the ratio of (3.00-1.00), 8.44 kg for the ratio of (2.00-2.00), 8.27 kg for theratio of (1:00-3.00), 6.93 kg for marketed suppository (Napa). The melting time of differentratios of Paracetamol suppositories are; 27 minutes at 37°C for the ratio of (3.35-0.65), 37minutes at 37°C for the ratio of (3.00-1.00), 1 hour at 37°C for the ratio of (2.00-2.00), 1 hourand 15 minutes at 37°C for the ratio of (1:00-3.00), 28 minutes at 37°C for marketedsuppository (Napa). The % release of different ratios of Paracetamol suppositories are;99.05% in 30 minutes for the ratio of (3.35-0.65), 98.53% in 30 minutes for the ratio of (3.00-1.00), 97.79% in 30 minutes for the ratio of (2.00-2.00), 96.33% in 30 minutes for the ratio of(1:00-3.00), 99.26% in 30 minutes for the ratio of marketed suppository (Napa) respectively.It is expected that present work will be helpful for the selection of appropriate ratio ofsuppository bases to get the maximum % release of drug.

Keywords: Paracetamol, Uniformity of weight, Hardness, Melting time, Dissolution (In vitro release study).