POLYMORPHIC CHARACTERIZATION OF TRAMADOL HYDROCHLORIDE USING DIFFERENTIAL SCANNING CALORIMETRY
Dushyanth Reddy Vennapu* and M. S. Palled
Abstract
The importance of polymorphism study for regulatory consideration in
the pharmaceutical industry is increasing day by day. Polymorphism is
defined as the ability of a compound to exist in different crystalline
forms in which the molecules have different arrangements in the
crystal lattice. Polymorphism is wide spread phenomena observed for
most of the drug substances. Different Polymorphs exhibit different
mechanical, thermal, physical & chemical properties, such as
compressibility, melting point, crystal habit, color, density, dissolution
rate & solubility. Polymorphism has great influence on the
bioavailability, hygroscopicity, stability, filtration & tableting.
Polymorphism can be evidenced by using a variety of experimental
techniques ranging from optical microscopy to more sophisticated methods of analysis such
as DSC, hot stage polarizing microscopy, x-ray powder diffraction etc.
Keywords: Compressibility, melting point, crystal habit, color, density, dissolution rate & solubility.
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