Abstract

EVALUATION OF CARDIO-PROTECTIVE ACTIVITY OF JATIPHALA (MYRISTICA FRAGRANS HOUTT.) IN WISTAR RATS

Dr. Manjunath H. Dundi*, Dr. Arun M. Chougale and Dr. Nayana K. Hashilkar

Abstract

Objective: To evaluate the cardioprotective activity of Jatiphala(Myrstica fragrans Houtt.) in male wistar rats. Among cardiovascular disease, myocardial infarction is nowadays commonly found in all the age groups. Many treatment modalities are present to tackle with this condition, but despite of this there is high percentage of re-occurrence and also increase in the mortality rate due to Myocardial infarction. So keeping this point in consideration, an attempt is made to find a safer and cost effective drug which can be helpful in the prevention of Myocardial infarction in cardiovascular disease risk patients. Jaatiphala was choosen to test for its cardioprotective activity in the present study because in Bhavapraksha nighantu we found its cardioprotective effect. Materials and Methods: Jatiphala churna was prepared using raw drug collected from natural habitat and after authentication by experts. Either sex wistar rats obtained from licensed breeder were divided into 3 groups- control group, ISO induced group and Pretreated group with Jatiphala churna. Control was given with normal water and food for 30 days, ISO group was also given with normal water and food for 30 days along with Inj. Isoproterenol on 29th and 30th day, Pretreated group was given with Jatiphala churna for 30 days along with Inj. Isoproterenol on 29th and 30th day. After completion of experiment rats were sacrificed and blood along with dissected heart was sent for serum estimation (SGOT, SGPT, CPK-MB and LIPID PROFILE) and Histo- pathology studies. Results: Pretreated group with Jatiphala churna showed significant effect in case of SGOT, CPK-MB and CHOLESTROL when compared with the ISO treated group. Non-significant effect was observed in case of LDL, HDL, TRIGLYCERIDES and SGPT. Conclusion: The result of present study indicated that the prior administration of churna of Myristica fragrans Houtt. attenuates Isoproterenol induced MI.

Keywords: Jatiphala, Cardioprotective, Isoproterenol.