Abstract

COMPARISON OF DIFFERENT TREATMENT CHOICE IN ASTHMATIC SMOKERS

N.Premkumar*, J.N.Dharsana, Jayakrishnan.S.S

Abstract

Objective: The primary objective of this study was to determine the treatment choice in asthmatic smokers and whether the drug of choice improved the lung function and quality of life. Study design: The present study was an open labeled study, conducted for a period of two years with mild to severe asthmatic smokers. The study was carried out in a tertiary care hospital and Private clinics in North Malabar region of Kerala. Participants were 99 regular smokers with breathlessness: 45 were diagnosed asthma and received different treatment choice. Results: All 45 patients received different treatment choice, 24% montelukast, 42% theophyline, 34%Tiotropium were included in asthma therapy. Montelukast added asthma therapy in asthmatic smokers, baseline FEV1 (1.52±0.30) and 90th day follow-up FEV1 (2.2±0.30) therapy had showed 0.68 units clinical improvement in pulmonary function test and QoL improvement had showed -24.2 units, when compared to Tiotropium and theophyline. Conclusion: In this study, patients with asthma who smoke, adjuvant therapy should be add-on therapy to attain asthma control. Montelukast combined therapy achieved better lung function and quality of life compared to Tiotropium and Theophyline in asthmatic smokers.

Keywords: asthma, Tiotropium and theophyline.