Abstract

FORMULATION AND EVALUATION OF ONCE-DAILY SUSTAINED RELEASE ACECLOFENAC DENDROPTHOE FALCATA GUM MATRIX TABLETS

Abstract

The main aim of the present investigation was to develop matrix tablets of aceclofenac with dendropthoe falcata gum and to study its functionality as a matrix forming agent for once daily sustained release tablet formulations. Physicochemical properties of dried powdered dendropthoe falcata gum were studied. Various formulations of aceclofenac dendropthoe falcate gum were prepared. The formulated tablets found to have better uniformity of weight and drug content with low sd values. The swelling behavior and release rate characteristics were studied. The dissolution study proved that the dried dendropthoe falcata gum can be used as a matrix forming material for making once daily sustained release matrix tablets.

Keywords: Aceclofenac, Dendropthoe falcata, matrix tablets, once daily sustained release.