Abstract

SYNTHESIS, ANTIINFLAMMATORY AND ANTIOXIDANT ACTIVITY OF N-(BENZOXAZOL-2-YL)-2-(2-OXOINDOLIN-3- YLIDINE)HYDRAZINE CARBOTHIOAMIDES

Arunadevi Parlapalli*, Raparthi Vijay Kumar, Manasa Cidda and Sarangapani Manda

Abstract

A series of seven new compounds were synthesized. Seven different isatins were utilized for condensing with N-(Benzoxazol-2- yl)hydrazine carbothioamide. The investigation of antiinflammatory activity revealed that the test compounds Vc (R=5-NO2), Vd (R=5-Br) & Va (R=5-H) significantly reduced the inflammation, there by showed a promising antiinflammatory activity towards carrageenan induced paw edema rat model, when compared to the standard drug indomethacin. Among these compounds, compound Va (R=5-H) & Ve (R=5-CH3) showed comparatively more antioxidant activity.

Keywords: Isatin, Benzoxazole, Antiinflammatory, antioxidant.