Abstract

PHYTOCHEMICAL INVESTIGATION AND EVALUATION OF ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF GMELINA ARBOREA ROXB ROOT

Sangram K. Panda*, Debajyoti Das, Suchismita Pani and Subhashree Padhy

Abstract

Medicinal plants are widely used by the traditional medicinal practitioners to cure various diseases due to their world-wide availability and less side effect. The present investigation was aimed at investing phytochemical constituents and anticonvulsant activity of ethanolic root extracts of Gmelina arborea Roxb. The phytochemical investigation is done by using various chemical analysis and standard methods. The anticonvulsant effect of ethanolic extract was studied by using maximum electroshock (MES) or pentylenetetrazole (PTZ) in male mice. The root extract of G. arborea (orally) was administered in mice at the doses of 100 and 200 mg/kg. The extract suppressed hind limb tonic extensions (HLTE) induced by MES and also exhibited protector effect in PTZ-induced seizures, at 200 mg/kg dose. Data from this study show that the extract significantly increases the onset time and decreases the duration of seizures by electroconvulsive shock. The study also revealed that the onset of tonic convulsion produced by PTZ was significantly delayed and also duration of seizures was prolonged. it is concluded that the ehanolic root extract of G. arborea exert their anticonvulsant effect.

Keywords: Gmelina arborea, Anticonvulsant effects, Maximal electroshock, Pentylenetetrazole.