PHYTOCHEMICAL INVESTIGATION AND EVALUATION OF ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF GMELINA ARBOREA ROXB ROOT
Sangram K. Panda*, Debajyoti Das, Suchismita Pani and Subhashree Padhy
Abstract
Medicinal plants are widely used by the traditional medicinal
practitioners to cure various diseases due to their world-wide
availability and less side effect. The present investigation was aimed at
investing phytochemical constituents and anticonvulsant activity of
ethanolic root extracts of Gmelina arborea Roxb. The phytochemical
investigation is done by using various chemical analysis and standard
methods. The anticonvulsant effect of ethanolic extract was studied by
using maximum electroshock (MES) or pentylenetetrazole (PTZ) in
male mice. The root extract of G. arborea (orally) was administered in
mice at the doses of 100 and 200 mg/kg. The extract suppressed hind
limb tonic extensions (HLTE) induced by MES and also exhibited
protector effect in PTZ-induced seizures, at 200 mg/kg dose. Data from this study show that
the extract significantly increases the onset time and decreases the duration of seizures by
electroconvulsive shock. The study also revealed that the onset of tonic convulsion produced
by PTZ was significantly delayed and also duration of seizures was prolonged. it is concluded
that the ehanolic root extract of G. arborea exert their anticonvulsant effect.
Keywords: Gmelina arborea, Anticonvulsant effects, Maximal electroshock, Pentylenetetrazole.
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