Abstract

FORMULATION AND DEVELOPMENT OF LUTEIN LOADED NANOPARTICLES

Neeraj Bhadkariya*, Akanksha Garud, Mukul Tailang and Navneet Garud

Abstract

The present research was aimed at formulation and development of lutein loaded nanoparticles by nanoprecipitation method using ethyl cellulose as polymer. Lutein is present in retina of eye but humans are not able to synthesize it, therefore it has to be obtained through dietary lutein intake. Lutein is natural antioxidant and natural sense of sight enhancer. Lutein helps in age related macular degradation. Optimization of selected parameters including the type of solvent, stirring time, drug polymer ratio and centrifugation speed were performed to obtain polymeric nanoparticles with optimum attributes. The prepared nanoparticles were evaluated for surface morphology, particle size, polydispersity index, zeta potential, entrapment efficiency and in-vitro drug release. Burst release of drug was observed at simulated intestinal pH (pH 6.8). The development of lutein loaded nanoparticles would be beneficial for better absorption of lutein.

Keywords: Lutein, antioxidant, ethyl cellulose, nanoprecipitation.