Abstract

DIMETHOATE INDUCED ALTERATION IN SERUM BIOCHEMICAL PARAMETERS IN RATTUS RATTUS

Yaqoob Lone, Abhilasha Chaurasia*, Muzaffar Ahmad Bhat and Rayees Ahmad Naik and Raj Kumar Koiri

Abstract

Dimethoate is an organophosphorus insecticide used for the control of a wide range of insects, including mites and houseflies on a variety of vegetables, fruits, fields and forestry crops. The aim of the present study was to evaluate the toxicity of orally administered dimethoate in Wistar albino rats, based on the biochemical findings in the serum. The animals of the exposed groups were orally administered 1mg/kg/alternate day dimethoate (30 EC, 98.4% pure) for 15 and 30 days respectively under controlled laboratory conditions. At the end of the experiment, body weight, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), alkaline phosphatase (ALP), acid phosphatase (ACP), creatinine and urea levels were determined. Results showed that there were decreases in body weights of exposed rats while the level of sGOT, sGPT, ALP, ACP, creatinine and urea in serum were significantly increased in both 15 and 30 days exposed rats. The present study indicates that dimethoate induces changes in biochemical parameters of liver and kidney of exposed rats inducing hepatotoxicity and nephrotoxicity.

Keywords: Dimethoate, Biochemical Parameters, Rats.